abstract：:Cholinergic system in the central nervous system is involved in the memory function. Thus, because the dysfunction of cholinergic system that project to the cerebral cortex from nucleus basalis of Meynert (nbM) would be implicated in the memory function deficits in Alzheimer's disease (AD), evaluating cholinergic func...

journal_title：Nuclear medicine and biology

authors： Ogawa M,Iida Y,Nakagawa M,Kuge Y,Kawashima H,Tominaga A,Ueda M,Magata Y,Saji H

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Comparative imaging of multiple radiotracers in the same animal can be invaluable in elucidating and validating their respective mechanisms of localization. Comparative imaging of PET tracers, particularly in small animals, is problematic, however: such tracers must be administered and imaged separately be...

journal_title：Nuclear medicine and biology

authors： Zanzonico P,Campa J,Polycarpe-Holman D,Forster G,Finn R,Larson S,Humm J,Ling C

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:In vivo reporter genes can be powerful tools in supporting and ensuring the success of gene therapy. A careful and rational design of a reporter system is essential to realize a noninvasive in vivo reporter gene imaging system applicable for humans. We designed a new in vivo reporter gene imaging system that us...

journal_title：Nuclear medicine and biology

authors： Furukawa T,Lohith TG,Takamatsu S,Mori T,Tanaka T,Fujibayashi Y

更新日期：2006-01-01 00:00:00

abstract：:Copper-64-labeled monoclonal antibodies (mAbs) have previously demonstrated unexpectedly effective tumor control in rodent models of cancer at relatively low tumor-absorbed radiation doses. This property has been associated with delivery platforms resulting in cellular internalization. The purpose of the present studi...

journal_title：Nuclear medicine and biology

authors： Bryan JN,Jia F,Mohsin H,Sivaguru G,Miller WH,Anderson CJ,Henry CJ,Lewis MR

更新日期：2005-11-01 00:00:00

abstract：:As PET metabolic imaging becomes routine in clinical practice, there is a tendency to make imaging and data analysis fast and simple, but interpretation of these pictures by visual inspection does not do justice to the power of PET technology. Tissue data and blood data can be analyzed mathematically to provide parame...

journal_title：Nuclear medicine and biology

authors： Krohn KA,Mankoff DA,Muzi M,Link JM,Spence AM

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Pretargeting is the concept that combines optimal delivery of the antibody and rapid capture and elimination of the radioactivity. In this study, we evaluated the potential of antibody pretargeting to enable the tumor-targeting (212)Pb for in vivo generation of (212)Bi for alpha particle radiotherapy. METHOD...

journal_title：Nuclear medicine and biology

authors： Su FM,Beaumier P,Axworthy D,Atcher R,Fritzberg A

更新日期：2005-10-01 00:00:00

abstract：:We have synthesized three different PET ligands to investigate the physiological function of metabotropic glutamate subtype 5 receptors (mGluR5) in vivo: 2-[(11)C]methyl-6-(2-phenylethynyl)pyridine ([(11)C]MPEP), 2-(2-(3-[(11)C]methoxyphenyl)ethynyl)pyridine ([(11)C]M-MPEP) and 2-(2-(5-[(11)C]methoxypyridin-3-yl)ethyn...

journal_title：Nuclear medicine and biology

authors： Yu M,Tueckmantel W,Wang X,Zhu A,Kozikowski AP,Brownell AL

更新日期：2005-08-01 00:00:00

abstract：METHODS:Anesthetized pigs were studied with [(11)C]-labeled fatty acids (FAs) with carbon chain length ranging from 8 to 16 carbon atoms, during control conditions and during inhibition of carnitine-palmitoyl transferase I (CPT I) with oxfenicine. The myocardial uptake of [(11)C]-FAs from blood was measured together wi...

journal_title：Nuclear medicine and biology

authors： Angsten G,Valind S,Takalo R,Neu H,Meurling S,Långström B

更新日期：2005-07-01 00:00:00

abstract：:The pyridopyrimidinones are a potent class of inhibitors of c-Abl kinase and Bcr-Abl kinase, the causative fusion protein in chronic myelogenous leukemia and Src family kinases. A novel method for routine, high-yield no-carrier-added synthesis of [(124)I]-, [(125)I]- and [(131)I]-6-(2,6-dichlorophenyl)-2-(4-iodophenyl...

journal_title：Nuclear medicine and biology

authors： Veach DR,Namavari M,Beresten T,Balatoni J,Minchenko M,Djaballah H,Finn RD,Clarkson B,Gelovani JG,Bornmann WG,Larson SM

更新日期：2005-05-01 00:00:00

abstract：:We are interested in imaging cell death in vivo using annexin V radiolabeled with (124)I. In this study, [(124)I]4IB-annexin V and [(124)I]4IB-ovalbumin were made using [(124)I]N-hydroxysuccinimidyl-4-iodobenzoate prepared by iododestannylation of N-hydroxysuccinimidyl-4-(tributylstannyl)benzoate. [(124)I]4IB-annexin ...

journal_title：Nuclear medicine and biology

authors： Dekker B,Keen H,Shaw D,Disley L,Hastings D,Hadfield J,Reader A,Allan D,Julyan P,Watson A,Zweit J

更新日期：2005-05-01 00:00:00

abstract：:We performed preclinical and clinical studies of O-[11C]methyl-L-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed s...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Tsukada H,Kubota K,Nariai T,Harada N,Kawamura K,Kimura Y,Oda K,Iwata R,Ishii K

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Cu-diacetyl-bis(N4-methylthiosemicarbazone) [Cu-ATSM], although excellent for oncology applications, may not be suitable for delineating cardiovascular or neurological hypoxia. For this reason, new Cu hypoxia positron emission tomography (PET) imaging agents are being examined to search for a higher selectiv...

journal_title：Nuclear medicine and biology

authors： McQuade P,Martin KE,Castle TC,Went MJ,Blower PJ,Welch MJ,Lewis JS

更新日期：2005-02-01 00:00:00

abstract：:A novel approach for the combinatorial synthesis of backbone-derived metal-cyclic peptide libraries is presented. In this approach the metalo-cyclic peptides are prepared from their linear precursors through complexation of a metal atom via two hemi-chelating arms located on the peptide backbone. Thus, cyclization and...

journal_title：Nuclear medicine and biology

authors： Fridkin G,Bonasera TA,Litman P,Gilon C

更新日期：2005-01-01 00:00:00

abstract：:A new positron emission tomography (PET) radioligand for the serotonin transporter (SERT), [(11)C]2-[2-[[(dimethylamino)methyl]phenyl]thio]-5-(2-fluoroethyl)phenylamine ([(11)C]AFE, 12), was synthesized and evaluated in vivo in rats and baboons. [(11)C]AFE (12) was prepared from its monomethylamino precursor 11 by rea...

journal_title：Nuclear medicine and biology

authors： Zhu Z,Guo N,Narendran R,Erritzoe D,Ekelund J,Hwang DR,Bae SA,Laruelle M,Huang Y

更新日期：2004-11-01 00:00:00

abstract：:Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [(166)Dy]Dy/(166)Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, i...

journal_title：Nuclear medicine and biology

authors： Pedraza-López M,Ferro-Flores G,Arteaga de Murphy C,Morales-Ramírez P,Piedras-Ross J,Murphy-Stack E,Hernández-Oviedo O

更新日期：2004-11-01 00:00:00

abstract：:In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial ...

journal_title：Nuclear medicine and biology

authors： Herrero P,Dence CS,Sharp TL,Welch MJ,Gropler RJ

更新日期：2004-10-01 00:00:00

abstract：:Antagonists of neurokinin receptors such as CP-643,051 are presently under investigation as potential antidepressants, but little is known about the brain uptake and distribution of these agents. We developed a method for the efficient N-[11C]methylation of CP-122,721, yielding the NK1 antagonist N-[11C]methyl CP-643,...

journal_title：Nuclear medicine and biology

authors： Bender D,Olsen AK,Marthi MK,Smith DF,Cumming P

更新日期：2004-08-01 00:00:00

abstract：:New oxotechnetium complexes of general formula [99mTc(O)(PNS)(S(CH2)nOSiR3)] (4-6) were synthesized by direct reduction of [99mTcO4]- with stannous chloride, in the presence of the tridentate heterofunctionalized phosphine H2PNS and of the monodentate silylated thiols [HS(CH2)nOSiR3] (n = 2, R = Ph (1); n = 3, R = Ph ...

journal_title：Nuclear medicine and biology

authors： Fernandes C,Kniess T,Gano L,Seifert S,Spies H,Santos I

更新日期：2004-08-01 00:00:00

abstract：:A radioiodinated ligand, (R)-N-methyl-(2-[(125)I]iodo-phenoxy)-3-phenylpropylamine, [(125)I]2-INXT, targeting norepinephrine transporters (NET), was successfully prepared. A no-carrier-added product, [(125)I]2-INXT, displayed a saturable binding with a high affinity (K(d)=0.06 nM) in the homogenates prepared from rat ...

journal_title：Nuclear medicine and biology

authors： Kung MP,Choi SR,Hou C,Zhuang ZP,Foulon C,Kung HF

更新日期：2004-07-01 00:00:00

abstract：:Stavudine, a potent antiviral agent for treating human immunodeficiency virus (HIV) infections, was radiolabeled with (11)C by methylation of a specifically designed precursor, 5'-O-(2-tetrahydropyranyl)-5-bromo-2',3'-didehydro-3'-deoxythymidine, with (11)C H(3)I. The radiolabeled drug was isolated by reverse phase HP...

journal_title：Nuclear medicine and biology

authors： Livni E,Berker M,Hillier S,Waller SC,Ogan MD,Discordia RP,Rienhart JK,Rubin RH,Fischman AJ

更新日期：2004-07-01 00:00:00

abstract：:The thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) is incorporated into DNA and is resistant to catabolism. We performed pharmacokinetic measurements with [(14)C]FMAU and PET studies with [(11)C]FMAU using rats bearing several different syngeneic tumors. Among normal tissues, FMAU uptake re...

journal_title：Nuclear medicine and biology

authors： Bading JR,Shahinian AH,Vail A,Bathija P,Koszalka GW,Koda RT,Alauddin MM,Fissekis JD,Conti PS

更新日期：2004-05-01 00:00:00

abstract：:The specific binding of [(11)C]doxepin, which has been used as a radioligand for mapping histamine H(1) receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [(11)C]doxepin uptake was reduced by treatment with cold doxepin and two H(1) receptor antagonists, but not...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Wang WF,Tsukada H,Harada N,Mochizuki H,Kimura Y,Ishii K,Iwata R,Yanai K

更新日期：2004-05-01 00:00:00

abstract：:Antimicrobial peptides have been proposed as new agents to distinguish between bacterial infections and sterile inflammatory processes. (99m)Tc-UBI labeled by a direct method has shown high in vitro and in vivo stability, specific uptake at the site of infection, rapid background clearance, minimal accumulation in non...

journal_title：Nuclear medicine and biology

authors： Meléndez-Alafort L,Rodríguez-Cortés J,Ferro-Flores G,Arteaga De Murphy C,Herrera-Rodríguez R,Mitsoura E,Martínez-Duncker C

更新日期：2004-04-01 00:00:00

abstract：:We have previously performed quantitative kinetic modeling of [(123)I]CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 hea...

journal_title：Nuclear medicine and biology

authors： Bressan RA,Erlandsson K,Mulligan RS,Gunn RN,Cunningham VJ,Owens J,Cullum ID,Ell PJ,Pilowsky LS

更新日期：2004-02-01 00:00:00

abstract：:The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-sta...

journal_title：Nuclear medicine and biology

authors： Perret P,Ghezzi C,Ogier L,Abbadi M,Morin C,Mathieu JP,Fagret D

更新日期：2004-02-01 00:00:00

abstract：:Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sen...

journal_title：Nuclear medicine and biology

authors： Liu Z,Stevenson GD,Barrett HH,Kastis GA,Bettan M,Furenlid LR,Wilson DW,Woolfenden JM

更新日期：2004-01-01 00:00:00

abstract：:The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocr...

journal_title：Nuclear medicine and biology

authors： Smith CJ,Volkert WA,Hoffman TJ

更新日期：2003-11-01 00:00:00

abstract：:A folate-receptor-targeting radiopharmaceutical, Ga(III)-deferoxamine-folate (Ga-DF-Folate), was radiolabeled with two positron-emitting isotopes of gallium, cyclotron-produced (66)Ga (9.5 hour half-life) and generator-produced (68)Ga (68 minute half-life). The [(66)Ga]Ga-DF-Folate was administered to athymic mice wit...

journal_title：Nuclear medicine and biology

authors： Mathias CJ,Lewis MR,Reichert DE,Laforest R,Sharp TL,Lewis JS,Yang ZF,Waters DJ,Snyder PW,Low PS,Welch MJ,Green MA

更新日期：2003-10-01 00:00:00

abstract：:A recently developed pinhole high-resolution SPECT system was used to measure striatal to non-specific binding ratios in rats (n = 9), after injection of the dopamine transporter ligand (123)I-FP-CIT, and to assess its test/retest reproducibility. For co-alignment purposes, the rat brain was imaged on a 1.5 Tesla clin...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,de Win MM,Lavini C,den Heeten GJ,Habraken JB

更新日期：2003-08-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：:[see text for equation] Nucleophilic [(18)F]fluorination of some halo- and mesyloxyalkanes to the corresponding [(18)F]fluoroalkanes with fluoride-18 obtained from an (18)O(p,n) [(18)F]F reaction, using an ionic liquid as a reaction medium, has been studied as a new method for fluorine-18 labeling. Of the various ioni...

journal_title：Nuclear medicine and biology

authors： Kim DW,Choe YS,Chi DY

更新日期：2003-05-01 00:00:00

abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

更新日期：2003-05-01 00:00:00

abstract：:Ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid), a widely-prescribed antibiotic, was labeled with fluorine-18 with the aim to perform positron emission tomography studies in humans for pharmacokinetic measurements. Due to a lack of chemical activation of ciproflox...

journal_title：Nuclear medicine and biology

authors： Langer O,Mitterhauser M,Brunner M,Zeitlinger M,Wadsak W,Mayer BX,Kletter K,Müller M

更新日期：2003-04-01 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) is a key enzyme involved in tumor invasiveness. (2R)-2- [4-(6-[(18)F]Fluorohex-1-ynyl)-benzenesulfonylamino]-3-methylbutyric acid ([(18)F]SAV03), a new fluorine-18 labeled MMP-2 inhibitor developed for tumor imaging with PET, was biologically evaluated using in vivo tumor model. Enzy...

journal_title：Nuclear medicine and biology

authors： Furumoto S,Takashima K,Kubota K,Ido T,Iwata R,Fukuda H

更新日期：2003-02-01 00:00:00

abstract：:The peripheral benzodiazepine receptor ligand PK11195 has been used as an in vivo marker of neuroinflammation in positron emission tomography studies in man. One of the methodological issues surrounding the use of the ligand in these studies is the highly variable kinetic behavior of [(11)C]PK11195 in plasma. We there...

journal_title：Nuclear medicine and biology

authors： Lockhart A,Davis B,Matthews JC,Rahmoune H,Hong G,Gee A,Earnshaw D,Brown J

更新日期：2003-02-01 00:00:00

abstract：:We examined transport of 3-[(125)I]iodo-alpha-methyl-L-tyrosine ([(125)I]IMT) in Xenopus laevis oocytes co-expressing human L-type amino acid transporter 1 (a component of system L) and human 4F2hc. Human LAT1 mediated transport of [(125)I]IMT. [(125)I]IMT uptake was decreased by the presence of L-isomers of Cys, Leu,...

journal_title：Nuclear medicine and biology

authors： Shikano N,Kanai Y,Kawai K,Ishikawa N,Endou H

更新日期：2003-01-01 00:00:00

abstract：UNLABELLED:Several radiopharmaceuticals and imaging techniques are proposed for breast cancer imaging. Since limited data are available of the uptake of SPECT and PET radiopharmaceuticals in malignant breast tumors and their metastases the aim of this study was to compare the uptake values and to correlate these data w...

journal_title：Nuclear medicine and biology

authors： Palmedo H,Hensel J,Reinhardt M,Von Mallek D,Matthies A,Biersack HJ

更新日期：2002-11-01 00:00:00

abstract：:We prepared 5-HT(1A) receptor ligands (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]-3-[11C]methylthiobenzamide ([11C](S)-PPMMB) (Ki = 4.3 nM) and the less active [(11)C](R)-PPMMB (Ki = 160 nM) by reduction of the disulfide dimer and subsequent [(11)C]methylation of demethyl (S)- and (R)-PPMMB, respectively. Both ra...

journal_title：Nuclear medicine and biology

authors： Fujio M,Nagata S,Kawamura K,Sugiyama N,Tanaka H,Uno K,Ishiwata K

更新日期：2002-08-01 00:00:00

abstract：:3-Amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile, labeled with carbon-11 ([11C]-DASB), is a recently introduced radiotracer for imaging the serotonin transporter (SERT) by positron emission tomography (PET). A series of in vitro and in vivo experiments were performed to further characterise the properties...

journal_title：Nuclear medicine and biology

authors： Wilson AA,Ginovart N,Hussey D,Meyer J,Houle S

更新日期：2002-07-01 00:00:00

abstract：:Holmium-166 ferric hydroxide macroaggregate (Ho-166 FHMA) particles possess two important properties for radiosynovectomy; relatively short half-life of the radioisotope and appropriate carrier size. Both these minimize radioactive leakage from the treated joint. This study was conducted to assess the effects of Ho-16...

journal_title：Nuclear medicine and biology

authors： Mäkelä O,Penttilä P,Kolehmainen E,Sukura A,Sankari S,Tulamo RM

更新日期：2002-07-01 00:00:00